11 PhD positions for applicants from the natural sciences


Available Positions

The i-Target doctoral program offers financial support for 11 PhD positions for applicants from the natural sciences for the following projects A to K.

Applications are only possible online using the following link: portal.graduatecenter-lmu.de/i-target. The application portal will be open from may May 19th through June 20th 2014. For any inquiries concerning the program or the application process, please contact the i-Target staff: itarget@med.uni-muenchen.de. Please note that applications submitted by email will not be considered.

Research Area 1: Targeted cellular therapy

  • A: Arming tumor specific T cells with CC motive receptors

    Principle investigators: PD Dr. Sebastian Kobold and Prof. Stefan Endres

    Brief description: Adoptive T cell therapy is one of the most promising approaches for the treatment of cancer. A major limitation is the infiltration or homing of the transferred T cells to the tumor site. The aim of this PhD-project will be to overexpress defined chemokine receptors on tumor-specific T cells to enhance the efficacy of adoptive T cell therapy. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

  • B: Enhancing T cell therapy through activating receptors

    Principle investigators: PD Dr. Sebastian Kobold and Prof. Stefan Endres

    Brief description: Tumors mount an effective immunosuppressive milieu to prevent immune cells to efficiently recognize tumor cells and suppress their activity. The aim of this Ph. D. project will be to overexpress in-house engineered activating receptors to enhance the efficacy of adoptive T cell therapy. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

  • C: Engagement of T cells through bispecific antibodies

    Principle investigators: PD Dr. Sebastian Kobold and Prof. Stefan Endres

    Brief description: Bispecific antibodies have the great advantage of specific targeting of two different antigens, allowing for both immune and tumor cell binding. The aim of this Ph. D. project will be to design and use new bispecific antibodies to enhance the efficacy of adoptive T cell therapy. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

  • D: Therapeutic vaccines and immune check point blockade in leukemia

    Principle investigator: PD Dr. Marion Subklewe; Department of hematology / oncology, University Hospital of the Ludwig-Maximailians-Universität, Munich, Germany

    Brief description: We have documented the generation of superior dendritic cells (DCs) from monocytes of AML patients using a fast, TLR ligand-containing maturation cocktail. Based on our preclinical data, we have initiated a proof-of-concept trial using RNA-transfected DCs for postremission therapy in AML. Therapeutic vaccinations induced cellular immune responses may be hampered by upregulation of immune inhibitory molecules (“immune checkpoint markers”) on target cells.

    The aim of this Ph.D. project is to identify immuninhibitory pathways relevant in AML as mechanisms of immune escape and as therapeutic targets. The therapeutic potential of checkpoint inhibitors and other immunmodulatory drugs will be assessed in vitro and in collaboration also in an in vivo AML mouse model. The methods will comprise a wide range of cellular and immunological methods and will optionally include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Medizinische-Klinik-und-Poliklinik-III/de/team/oberaerzte/subklewe_m

 

Research Area 2: Targeted immunomodulatory therapy

  • E: Development of innovative multispecific antibody derivatives for the specific recruitment of immune effector cells to tumor cells

    Principle investigator: Prof. Dr. rer. nat. Karl-Peter Hopfner

    Brief description: The project will involve a combination of protein engineering, protein biochemistry and functional studies (cell culture, cell lysis assays, FACS). In collaboration with other iTarget members, the final goal of the PhD thesis is to test the efficacy in mouse models.

    Homepage: www.hopfner.genzentrum.lmu.de

  • F: Identifying novel immunological epitopes for immunotherapy of acute myeloid leukemia.

    Principle investigators: Prof. Dr. Christoph Klein, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University, Munich, Germany.

    Brief description: In this Phd project we plan to develop a research pipeline to discover novel therapeutic targets for AML by deciphering key factors controlling myeloid cell differentiation. Thus we wish to study the potential role of novel targets in murine leukemia cells as well as the identification of novel pathways via genome-wide analysis of rare children with monogenetic diseases. We plan to design monoclonal antibodies and chimeric T-cell receptors recognizing specific membrane-bound proteins and anticipate that immune-targeting will selectively eliminate myeloid cells. Immune-effectors will be systematically assessed in vitro and in vivo for their capacity to recognize and kill myeloid leukemia cells. The methods will comprise a wide range of cellular, immunological and biochemical methods as well as in vivo experiments.

    Homepage: www.klein.genzentrum.lmu.de

  • G: Induction of anti-leukemic T-cell responses by bystander killing of CD33+ myeloid-derived suppressor cells via a CD33/CD3-bispecific BiTE® antibody construct

    Principle investigators: Prof. Dr. Andreas Mackensen and PD Dr. Dimitrios Mougiakakos, Department of Hematology and Oncology, University Hospital, Friedrich-Alexander-University, Erlangen, Germany

    Brief description: In recent years myeloid derived suppressor cells (MDSCs) have emerged as a key cell subset that promotes tumor immune escape. Strategies to overcome MDSC-mediated immune suppression hold promise to improve efficacy of modern immunotherapies. The aim of this PhD project is to (1) characterize MDSCs in patients with acute myeloid leukemia (AML) in order to (2) target them with a novel so-called CD33/CD3 bi-specific antibody (AMG330) showing a high anti-leukemic activity. In doing so we hope elicit two critical hits against AML. The methods utilized in this translational project will comprise a broad variety of cellular, molecular, and immunological techniques.

    Homepage: www.medizin5.uk-erlangen.de/en/research-teaching

 

Research Area 3: Targeted immunomodulatory therapy

  • H: Harnessing immune responses in hematological malignancies by redox remodeling

    Principle investigators: PD Dr. Dimitrios Mougiakakos and Prof. Dr. Andreas Mackensen, Department of Hematology and Oncology, University Hospital, Friedrich-Alexander-University, Erlangen, Germany

    Brief description: Emerging evidence suggest that tumor-associated oxidative stress weakens the patients’ immune system and thereby contributes to tumor immune escape and attenuates the efficacy of immune based therapies. In this PhD project we aim to (1) evaluate oxidative stress-induced immune alterations in patients with leukemia and to develop strategies for pharmacologically (2) antagonizing this metabolic condition and for (3) enhancing the resilience of immune cells towards it. The ultimate goal is to boost intrinsic anti-tumor immune responses and to increase the efficacy of immune based therapies. The methods utilized in this translational project will comprise a broad variety of cellular, immunological, and metabolic techniques.

    Homepage: www.medizin5.uk-erlangen.de/en/research-teaching

  • I: Combination of radiotherapy with Hsp90 inhibition to enhance the extent and the immunogenicity of tumor cell death for the treatment of sarcoma

    Principle investigators: Prof. Kirsten Lauber, Clinic for Radiotherapy and Radiation Oncology, Ludwig-Maximilians-Universität, Munich, Germany

    Brief description: The induction of immunogenic forms of cell death by specific radiotherapeutic regimes appears to be a promising approach for the stimulation of innate and adaptive anti-tumor immune responses. The aim of this PhD project is to explore, whether Hsp90 inhibition in combination with radiotherapy can enhance the extent as well as the immunogenicity of sarcoma cell death, and whether this can contribute to the stimulation of anti-sarcoma immune responses. To this end, various molecular, cell biological, and immunological methods will be employed, including in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Klinik-und-Poliklinik-fuer-Strahlentherapie-und-Radioonkologie/de/forschung/molek_onkologie/index.html

  • J: Card9 signaling in anti-tumor immunity

    Principle investigator: Prof. Jürgen Ruland, Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar der Technischen Universität München

    Brief description: T cell activation is controlled by signals from antigen-presenting cells (APCs). APCs express multiple distinct pattern recognition receptors that can respond to specific innate immune stimuli and trigger unique signaling pathways that can prime T cell responses in a differential manner. The downstream adapter protein Card9 is absolutely critical for this process. Using in vitro and in vivo techniques, the PhD student will characterize the role of Card9 in the induction of T cell responses and tumor immunity. Another major aim of the project is to investigate the role of innate immune effectors on tumor growth and survival and their role in the tumor environment.
    Homepage: www.klinchem.med.tum.de

  • K: Targeting myeloid-derived suppressor cells (MDSC) in pancreatic cancer with ligands of RIG-I like helicases (RLH)

    Principle investigator: Prof. Max Schnurr, Division of Clinical Pharmacology, University Hospitals, Ludwig-Maximilians-Universität, Munich, Germany

    Brief description: Pancreatic cancer is characterized by an immunosuppressive network involving immature myeloid cells, so called MDSCs. Reprogramming MDSCs from an immunosuppressive (M2) towards an immunogenic (M1) phenotype is a novel therapeutic approach for breaking immunosuppression in tumors. The aim of this PhD project will be to assess the influence of immune stimulatory RNA species that activate the cytosolic helicase RIG-I on MDSC functional profiles, both tumor-promoting and -inhibitory. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments in murine pancreatic carcinoma models.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

Scholarships-MSc in Math Engg

 

Scholarships worth 48,000 euros to attend a European joint MSc in Mathematical Engineering.

MathMods is a two-year joint Master of Science (MSc) programme (120 ECTS) between 5 European universities, which aims to provide students with a cross cultural education while they get acquainted with both theory and applications of mathematical modelling in engineering.

Several cholarships are offered by the European Commission to both non- European and European students. These scholarships amount to a maximum of EUR 48,000.00 to cover the two-year expenses and are granted to the most promising applicants.

CONSORTIUM

The MathMods Consortium is coordinated by the

– University of L’Aquila in Italy (UAQ)

and involves other four leading institutions in Europe:

– Autonomous University of Barcelona in Catalonia (UAB),

– Gdansk University of Technology in Poland (GUT),

– University of Hamburg in Germany (UHH),

– University of Nice – Sophia Antipolis in France (UNS).

STUDY PROGRAMME

The MathMods Master’s degree course consists of four semesters. Each semester totals 30 ECTS credits. The mobility scheme involves two different locations at least. The first year is common for all students: this will guarantee an equal knowledge platform for all of them. The second year is divided into five paths, which reflect the partners’ field of excellence.

– First semester: Theory at UAQ, Italy

– Second semester: Numerics at UHH, Germany

– Third+Fourth semester: Applications at UAB / UHH / UAQ / GUT / UNSA

LANGUAGE

The language of the whole course is exclusively English at each of the five universities. Students must also attend (and acquire the relating credits of) a course of basic Italian language (first semester) and German language (second semester). Students will also have the opportunity to attend local language courses during their second year (spent at one of the five partners).

Further Information

Application Deadline : 31 January 2014

10 PhD Scholarships in Frankfurt School of Finance & Management

The Frankfurt School of Finance and Management is one of Germany’s leading business schools. Frankfurt School invites ambitious candidates to apply for its doctoral programme in finance, management, accounting and economics.

The programme is entirely taught in English and provides in-depth training and excellent research opportunities led by renowned scholars. Doctoral students in the programme learn and work in small teams. In their independent research and publication efforts they are guided by experienced faculty members.

The Frankfurt School of Finance and Management Stiftung offers

10 Doctoral Scholarships
including a tuition waiver and a stipend of EUR 1,200 per month

Outstanding graduates of a master programme in business administration, finance, economics, mathematics or a related field who aspire to launch an academic career are invited to apply. Students are expected to devote 100% of their working time to their doctoral studies at the Frankfurt School for at least three years.

All scholarships will be granted on the basis of academic criteria only.
The application deadline is 15 January 2014.

Universal Education Consultant

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If you want to study free or want to study abroad in Europe. then please contact to
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Scholarship Master in Economics and Management of Network Industries

  • From November 1st 2013 to January 15th 2014.
  • Students applying without scholarship: To be open in February..

PLEASE CLICK HERE TO START SUBMITTING YOUR APPLICATION

The liberalization and regulation of network industries and infrastructures across the world creates a need for industries and public institutions to hire skilled professionals capable of understanding these processes and participating actively in their management and regulation.

The EMIN Joint Master Programme offers the opportunity to acquire expertise in the management of network industries from a global perspective that covers both economic/regulatory and technological/management issues. In these industries, teaching, training and research are typically carried out solely by focused specialists, which usually results in a skewed perspective. The purpose of this Master is to continue integrating specialists from different backgrounds and nationalities, and to make them interact in an interdisciplinary program so as to address the main problems faced by network industries in the current context of economic crisis and environmental concern. Our master students will learn the relevant engineering, economics, policy and management principles that should guide the functioning of network and infrastructure industries with a special focus on the energy and electrical power sector. Throughout the master, students will apply these skills and knowledge to solve real-life problems, since this course is dedicated to training qualified professionals.

This Master Programme is awarded jointly by some of the most prestigious European universities. First line American and Asian universities and research institutes are also part of the programme consortium.

The EMIN Joint Master Programme was awarded in 2006 the Erasmus Mundus excellence label by the European Commission. This award was renewed for another 5 years in 2010. Therefore, scholarships granted by the European Commission will be available both for EMIN students and visiting professors during the forthcoming years. The Erasmus Mundus excellence label has only been granted so far to 126 Masters and 34 doctorates in all disciplines and Universities across Europe. Comillas also coordinates the Erasmus Mundus Joint Doctorate in Sustainable Energy Technologies and Strategies (SETS Joint Doctorate).

The Erasmus Mundus programme aims to enhance quality in higher education through scholarships and academic cooperation between Europe and the rest of the world.

Added Value

The EMIN Joint Master Programme has an advantage over existing programmes in the added value stemming from its partners’ joint expertise, the relevance of the subjects addressed, the participation of supporting industries and institutions, and the target of offering a joint degree once legal obstacles and national legislation so allow. All these advantages ensure an impact on European competitiveness in this area, and the development of cutting-edge education and collaboration between the academic and the industrial worlds. This added value of the EMIN Joint Master Programme can be summarized in the following points: international component, renowned partners, interdisciplinary approach, industry connection, experience gained in the management of this programme, and research career opportunities.

Universal Education Consultant

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If you want to study free or want to study abroad in Europe. then please contact to
28 countries in Europe, visa for all
apply@ueconultant.com, info@ueconsultant.com

 

Scholarship MSc in Dependable Software Systems

Awarded Best New Postgraduate Course of 2013

**Scholarship Applications for September 2014 student intake close on 15th January, 2014** 

**Teaching Scholar Applications welcome at any time**

Click on How To Apply for further information.

The National University of Ireland Maynooth (NUIM) in Ireland; the University of St. Andrews (UStA) in Scotland; and Université de Lorraine, Nancy (UL) in France are offering a two-year double Master Programme, named Erasmus Mundus MSc in Dependable Software Systems (DESEM) Click here to download the Brochure.

Course Objective: Our objective is to provide students with the knowledge, skill and in-depth technical understanding of the key concepts required to design and build dependable software systems. This will be achieved by bringing together the theory and practice of software development and, in particular, through the transfer of knowledge from the classroom via research driven and commercially relevant projects.

Degree Description: The double-degree will be achieved over two years, through the allocation of 120ECTS. Students will study in two of the three partner universities, achieving a diploma supplement from each university in which they accomplish 60ECTS from the DESEM Programme.

A student will achieve the double Erasmus Mundus MSc in Dependable Software Systems, through studying the relevant course components at two of the three partner universities.

– See more at: http://www.cs.nuim.ie/courses/desem/#sthash.6q06vD4Q.dpuf