11 PhD positions for applicants from the natural sciences


Available Positions

The i-Target doctoral program offers financial support for 11 PhD positions for applicants from the natural sciences for the following projects A to K.

Applications are only possible online using the following link: portal.graduatecenter-lmu.de/i-target. The application portal will be open from may May 19th through June 20th 2014. For any inquiries concerning the program or the application process, please contact the i-Target staff: itarget@med.uni-muenchen.de. Please note that applications submitted by email will not be considered.

Research Area 1: Targeted cellular therapy

  • A: Arming tumor specific T cells with CC motive receptors

    Principle investigators: PD Dr. Sebastian Kobold and Prof. Stefan Endres

    Brief description: Adoptive T cell therapy is one of the most promising approaches for the treatment of cancer. A major limitation is the infiltration or homing of the transferred T cells to the tumor site. The aim of this PhD-project will be to overexpress defined chemokine receptors on tumor-specific T cells to enhance the efficacy of adoptive T cell therapy. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

  • B: Enhancing T cell therapy through activating receptors

    Principle investigators: PD Dr. Sebastian Kobold and Prof. Stefan Endres

    Brief description: Tumors mount an effective immunosuppressive milieu to prevent immune cells to efficiently recognize tumor cells and suppress their activity. The aim of this Ph. D. project will be to overexpress in-house engineered activating receptors to enhance the efficacy of adoptive T cell therapy. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

  • C: Engagement of T cells through bispecific antibodies

    Principle investigators: PD Dr. Sebastian Kobold and Prof. Stefan Endres

    Brief description: Bispecific antibodies have the great advantage of specific targeting of two different antigens, allowing for both immune and tumor cell binding. The aim of this Ph. D. project will be to design and use new bispecific antibodies to enhance the efficacy of adoptive T cell therapy. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

  • D: Therapeutic vaccines and immune check point blockade in leukemia

    Principle investigator: PD Dr. Marion Subklewe; Department of hematology / oncology, University Hospital of the Ludwig-Maximailians-Universität, Munich, Germany

    Brief description: We have documented the generation of superior dendritic cells (DCs) from monocytes of AML patients using a fast, TLR ligand-containing maturation cocktail. Based on our preclinical data, we have initiated a proof-of-concept trial using RNA-transfected DCs for postremission therapy in AML. Therapeutic vaccinations induced cellular immune responses may be hampered by upregulation of immune inhibitory molecules (“immune checkpoint markers”) on target cells.

    The aim of this Ph.D. project is to identify immuninhibitory pathways relevant in AML as mechanisms of immune escape and as therapeutic targets. The therapeutic potential of checkpoint inhibitors and other immunmodulatory drugs will be assessed in vitro and in collaboration also in an in vivo AML mouse model. The methods will comprise a wide range of cellular and immunological methods and will optionally include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Medizinische-Klinik-und-Poliklinik-III/de/team/oberaerzte/subklewe_m

 

Research Area 2: Targeted immunomodulatory therapy

  • E: Development of innovative multispecific antibody derivatives for the specific recruitment of immune effector cells to tumor cells

    Principle investigator: Prof. Dr. rer. nat. Karl-Peter Hopfner

    Brief description: The project will involve a combination of protein engineering, protein biochemistry and functional studies (cell culture, cell lysis assays, FACS). In collaboration with other iTarget members, the final goal of the PhD thesis is to test the efficacy in mouse models.

    Homepage: www.hopfner.genzentrum.lmu.de

  • F: Identifying novel immunological epitopes for immunotherapy of acute myeloid leukemia.

    Principle investigators: Prof. Dr. Christoph Klein, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University, Munich, Germany.

    Brief description: In this Phd project we plan to develop a research pipeline to discover novel therapeutic targets for AML by deciphering key factors controlling myeloid cell differentiation. Thus we wish to study the potential role of novel targets in murine leukemia cells as well as the identification of novel pathways via genome-wide analysis of rare children with monogenetic diseases. We plan to design monoclonal antibodies and chimeric T-cell receptors recognizing specific membrane-bound proteins and anticipate that immune-targeting will selectively eliminate myeloid cells. Immune-effectors will be systematically assessed in vitro and in vivo for their capacity to recognize and kill myeloid leukemia cells. The methods will comprise a wide range of cellular, immunological and biochemical methods as well as in vivo experiments.

    Homepage: www.klein.genzentrum.lmu.de

  • G: Induction of anti-leukemic T-cell responses by bystander killing of CD33+ myeloid-derived suppressor cells via a CD33/CD3-bispecific BiTE® antibody construct

    Principle investigators: Prof. Dr. Andreas Mackensen and PD Dr. Dimitrios Mougiakakos, Department of Hematology and Oncology, University Hospital, Friedrich-Alexander-University, Erlangen, Germany

    Brief description: In recent years myeloid derived suppressor cells (MDSCs) have emerged as a key cell subset that promotes tumor immune escape. Strategies to overcome MDSC-mediated immune suppression hold promise to improve efficacy of modern immunotherapies. The aim of this PhD project is to (1) characterize MDSCs in patients with acute myeloid leukemia (AML) in order to (2) target them with a novel so-called CD33/CD3 bi-specific antibody (AMG330) showing a high anti-leukemic activity. In doing so we hope elicit two critical hits against AML. The methods utilized in this translational project will comprise a broad variety of cellular, molecular, and immunological techniques.

    Homepage: www.medizin5.uk-erlangen.de/en/research-teaching

 

Research Area 3: Targeted immunomodulatory therapy

  • H: Harnessing immune responses in hematological malignancies by redox remodeling

    Principle investigators: PD Dr. Dimitrios Mougiakakos and Prof. Dr. Andreas Mackensen, Department of Hematology and Oncology, University Hospital, Friedrich-Alexander-University, Erlangen, Germany

    Brief description: Emerging evidence suggest that tumor-associated oxidative stress weakens the patients’ immune system and thereby contributes to tumor immune escape and attenuates the efficacy of immune based therapies. In this PhD project we aim to (1) evaluate oxidative stress-induced immune alterations in patients with leukemia and to develop strategies for pharmacologically (2) antagonizing this metabolic condition and for (3) enhancing the resilience of immune cells towards it. The ultimate goal is to boost intrinsic anti-tumor immune responses and to increase the efficacy of immune based therapies. The methods utilized in this translational project will comprise a broad variety of cellular, immunological, and metabolic techniques.

    Homepage: www.medizin5.uk-erlangen.de/en/research-teaching

  • I: Combination of radiotherapy with Hsp90 inhibition to enhance the extent and the immunogenicity of tumor cell death for the treatment of sarcoma

    Principle investigators: Prof. Kirsten Lauber, Clinic for Radiotherapy and Radiation Oncology, Ludwig-Maximilians-Universität, Munich, Germany

    Brief description: The induction of immunogenic forms of cell death by specific radiotherapeutic regimes appears to be a promising approach for the stimulation of innate and adaptive anti-tumor immune responses. The aim of this PhD project is to explore, whether Hsp90 inhibition in combination with radiotherapy can enhance the extent as well as the immunogenicity of sarcoma cell death, and whether this can contribute to the stimulation of anti-sarcoma immune responses. To this end, various molecular, cell biological, and immunological methods will be employed, including in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Klinik-und-Poliklinik-fuer-Strahlentherapie-und-Radioonkologie/de/forschung/molek_onkologie/index.html

  • J: Card9 signaling in anti-tumor immunity

    Principle investigator: Prof. Jürgen Ruland, Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar der Technischen Universität München

    Brief description: T cell activation is controlled by signals from antigen-presenting cells (APCs). APCs express multiple distinct pattern recognition receptors that can respond to specific innate immune stimuli and trigger unique signaling pathways that can prime T cell responses in a differential manner. The downstream adapter protein Card9 is absolutely critical for this process. Using in vitro and in vivo techniques, the PhD student will characterize the role of Card9 in the induction of T cell responses and tumor immunity. Another major aim of the project is to investigate the role of innate immune effectors on tumor growth and survival and their role in the tumor environment.
    Homepage: www.klinchem.med.tum.de

  • K: Targeting myeloid-derived suppressor cells (MDSC) in pancreatic cancer with ligands of RIG-I like helicases (RLH)

    Principle investigator: Prof. Max Schnurr, Division of Clinical Pharmacology, University Hospitals, Ludwig-Maximilians-Universität, Munich, Germany

    Brief description: Pancreatic cancer is characterized by an immunosuppressive network involving immature myeloid cells, so called MDSCs. Reprogramming MDSCs from an immunosuppressive (M2) towards an immunogenic (M1) phenotype is a novel therapeutic approach for breaking immunosuppression in tumors. The aim of this PhD project will be to assess the influence of immune stimulatory RNA species that activate the cytosolic helicase RIG-I on MDSC functional profiles, both tumor-promoting and -inhibitory. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments in murine pancreatic carcinoma models.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

Italy : 101 PhD positions at University of Trento

Admission to Research Doctorate can be done only by public selection. Announcements for Selection are published every year between February and July. For details about examination&# 39;s schedule please refer to the webpages of the selected doctoral school.

Available applications for Doctoral courses by the University of Trento are listed below.

International Doctoral School in Biomolecular Sciences 29 cycle
Deadline Thu 26 Sep 2013 16:00 (Italian time)

PhD Program in Humanities 29th cycle
Deadline Wed 25 Sep 2013 16:00 (Italian time)

Doctoral School in Mathematics 29th cycle
Deadline Wed 18 Sep 2013 16:00 (Italian time)

Doctoral School in Civil, Environmental and Mechanical Engineering 29th cycle
Deadline Mon 30 Sep 2013 16:00 (Italian time)

Doctoral School in Materials, Mechatronics and System Engineering 29th cycle
Deadline Tue 24 Sep 2013 16:00 (Italian time)

Doctoral School in Physics 29th cycle
Deadline Tue 10 Sep 2013 16:00 (Italian time)

Doctoral Course in Comparative and European legal studies 29th cycle
Deadline Wed 18 Sep 2013 16:00 (Italian time)

Further Information

Application Deadline : 26 September 2013

Universita' di Trento

Doctoral courses

PhD courses available at the University of Trento for the academic year 2013/2014 (29° cycle):

Scientific Area:

Humanities Area:

Cognitive Area:

 

Admission to Research Doctorate can be done only by public selection. Announcements for Selection are published every year between February and July. For details about examination’s schedule please refer to the webpages of the selected doctoral school.

Available applications for Doctoral courses by the University of Trento are listed below.

Scientific Area Doctoral Courses – Doctorate Office – Science and technology
Via Sommarive 14 – 38123 Povo – Trento
tel. +39 0461 281667 – 1669 – 2194
fax +39 0641 281699
dottorati-collina@unitn.it
Office opening hours: from Monday to Friday: 10.00-12.00.

Humanities Area Doctoral Courses – Doctorate Office
Via Verdi, 26 – 38122 Trento
tel. +39 0461 282188-1753-2193-1428-2377
fax +39 0461 282191
dottorati-citta@unitn.it
Office opening hours: from Monday to Friday: 10.00-12.00; Tuesday: 14.00-16.00.

Cognitive Area Doctoral Courses – Doctorate Office Rovereto
Corso Bettini, 84 – 38068 Rovereto
tel. +39 0464 808416
fax +39 0464 808407
dottorati-rovereto@unitn.it
Office opening hours: Monday: 10.00-12.00; Wednesday: 14.30-16.00; Friday: 10.00-12.00.

 

International Doctoral School in Biomolecular Sciences 29 cycle
Deadline Thu 26 Sep 2013 16:00 (Italian time)
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PhD Program in Humanities 29th cycle
Deadline Wed 25 Sep 2013 16:00 (Italian time)
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Doctoral School in Civil, Environmental and Mechanical Engineering 29th cycle
Deadline Mon 30 Sep 2013 16:00 (Italian time)
Info Info Download Download
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CIBIO – Declaration of Interest Form 2013
Deadline Wed 02 Oct 2013 01:00 (Italian time)
Info Info
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Doctoral School in Materials, Mechatronics and System Engineering 29th cycle
Deadline Tue 24 Sep 2013 16:00 (Italian time)

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UNIRAZAK Master / PhD Research Scholarships for Malaysian and International Students, 2013/14

Universiti Tun Abdul Razak

Universiti Tun Abdul Razak (UNIRAZAK) is inviting applications for postgraduate research scholarships. These scholarships are awarded to pursue the degree of Master of Science (Management) or Doctor of Philosophy (Management). Each scholarship recipient will serve as graduate research assistant to the principal investigator and will also be assigned a research supervisor by the Graduate School of Business to guide him/ her to programme completion. Full time students are expected to devote half of their 40-hours week to the assigned research project and the other half to pursuing the completion of their degree and teaching or carrying out administrative duties as appropriate. In addition to the scholarship, research assistants will have the opportunity to receive stipends.

Study Subject (s): Scholarships are available to pursue the degree of Master of Science (Management) or Doctor of Philosophy (Management). Each scholarship recipient will serve as graduate research assistant to the principal investigator of one of the following research projects: Service innovation, Halal supply chain, Social network development, Sustainability management, Economic and social indicators, Emotional labour, Service commercialisations and Transgenerational entrepreneurship.
Course Level: Scholarships are awarded to pursue the postgraduate research program at Universiti Tun Abdul Razak.
Scholarship Provider: The postgraduate research scholarship is funded by the Government of Malaysia through theFundamental Research Grant Scheme (FRGS) and the Exploratory Research Grant Scheme (ERGS).
Scholarship can be taken at: Malaysia

Eligibility: This is an open competition; however, a different programme fee structure applies to international applicants. Applicants must fulfill general entry requirements set by the Graduate School of Business.

Scholarship Open for International Students: Malaysian and international students can apply for this scholarship.

Universiti Tun Abdul Razak

Scholarship Description: UNIRAZAK is now recruiting suitably qualified individuals to pursue the degree of Master of Science (Management) or Doctor of Philosophy (Management) at UniversitiTun Abdul Razak (UNIRAZAK). The postgraduate research scholarships are funded by the Government of Malaysia through the Fundamental Research Grant Scheme (FRGS) and the Exploratory Research Grant Scheme (ERGS). The award of scholarship to students undertaking a postgraduate research programme on a part-time basis will be at the discretion of the project’s principal investigator and scholarship panel. In addition to the scholarship, research assistants will have the opportunity to receive stipends. Date of commencement as a research assistant can be as early as 1St August, 2013. All postgraduate students will be required to attend a series of research related courses.

Duration of award (s): A full time student is expected to complete his/ her studies within the minimum duration of one (1) year for the Master of Science (Management) student or two (2) years since Doctor of Philosophy (Management). The continuity of this award will be based on the student’s academic performance and his/her fulfillment of the stipulated work requirements.

What does it cover? A postgraduate research scholarship covers the cost of LOCAL tuition fee amounting to RM16, 200 for Master of Science (Management) or RM24, 240 for Doctor of Philosophy (Management). These scholarships are not cash awards, however, research assistants may receive stipend, as previously stated.

How to Apply: In order to be considered for these scholarships, applicants must complete the following:
-online application for admission to the Graduate School of Business; and
-Postgraduate Research Scholarship Application Form.
Email the Postgraduate Research Scholarship Application Form together with a letter of interest, to Dr. Dewi Amat Sapuan, Bureau for Excellence in Research and Teaching, at dewi-at-unirazak.edu.my. Please state “2013 – 2014 UPRS” as a subject.

Scholarship Application Deadline: The application deadline is 29th July, 2013.

Universal Education Consultant

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Berlin Doctoral Program in Economics and Management Science (BDPEMS)

© David Ausserhofer © Heike Zappe

Benefit from a unique research environment

Berlin Doctoral Program in Economics and Management Science (BDPEMS)

Embedded in Berlin’s unique and manifold academic environment, the Berlin Doctoral Program in Economics and Management Science (BDPEMS) provides outstanding doctoral students with state-of-the-art training in economics, finance, econometrics, and management science. The program offers scholarships of up to three years depending on academic excellence and study performance.

BDPEMS at a glance

  • Structured doctoral education in economics and management science
  • Financial support in the form of scholarships
  • Broad network of institutions and researchers
  • Fast track for students with a bachelor’s degree
  • International focus
  • and – last but not least – the inspiring research atmosphere of Germany’s capital.

The program prepares students for cutting-edge research in a broad range of fields by following leading international standards, with an emphasis on rigorous analytical methods and quantitative analysis. It provides core education in macroeconomics, microeconomics, management science, and econometrics.

The faculty consists of internationally renowned scholars from:
Humboldt-Universität zu Berlin
Freie Universität Berlin
Technische Universität Berlin
European School of Management and Technology (ESMT)
Social Science Research Center Berlin (WZB)

The program cooperates with the Graduate Center of the German Institute for Economic Research (DIW).

Universal Education Consultant
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2013/14 ARUS International Doctoral Program at University of Duisburg-Essen in Germany Read more: 2013/14 ARUS International PhD Program : 2013 2014 Scholarship Positions

University of Duisburg-Essenof Duisburg-Essen offers ARUS International Doctoral Program in Germany. International doctoral candidates can apply for this scholarship. The scholarship is provided for Advanced Research in Urban Systems (ARUS). Two scholarships are offered for the tenure of six semesters (3 years). The scholarship covers a stipend of € 1,000.00 / month. Scholarships are available in graduates ARUS engineering, planning, space, social sciences and humanities courses that locate their research subjects in an urban context. The International Doctoral Program application closing date is April 30, 2013. Applications should be sent by post.

Study Subject(s): The scholarship is provided for Advanced Research in Urban Systems (ARUS). Placing great emphasis on trans-departmental collaboration and interdisciplinary research on crucial issues in urban studies.
Course Level: This scholarship is for pursuing PhD degree level.
Scholarship Provider: German Academic Exchange Service (DAAD) and Federal Ministry of Education and Research (BMBF)
Scholarship can be taken at: Germany

Eligibility: -The program is ARUS Aimed at graduates with backgrounds in the social sciences, humanities, education, engineering, or urban planning.
-Graduates from Germany and abroad (or Comparable Masters degree, with above-average final marks) can apply.

Scholarship Open for Students of Following Countries: Graduates from Germany and abroad can apply for this program.University of Duisburg-Essen

Scholarship Description: Training for reflection competent experts for the sustainable development of urban space with career opportunities in science and practice. The scientific study of the graduates will enable ARUS identify in prominent positions with responsibility complex urban problems, to describe, to analyze, to find solutions and to accompany their successful implementation competent.

Number of awards offered: Two scholarships are awarded.

Duration of award(s): ARUS is a demanding three-year research program of high academic quality and offers candidates a variety of academic advising and support opportunities. Selected foreign doctoral students receive a stipend of € 1,000.00 / month granted over three to four years.

What does it cover? ARUS and the DAAD award two scholarships (1000 € per month for two years, option for extension) for dissertations (in English or German) to be written by a foreign student (students from emerging nations are preferred) in the field of urban studies.

Selection Criteria: Not Known

Notification: Not Known

How to Apply: By submitting the application, applicants are applying for a scholarship automatically. If they are among the best candidates / inside, then they will receive a scholarship.

Scholarship Application Deadline: The International PhD application closing date is April 30, 2013.

Further Official Scholarship Information and Application