11 PhD positions for applicants from the natural sciences


Available Positions

The i-Target doctoral program offers financial support for 11 PhD positions for applicants from the natural sciences for the following projects A to K.

Applications are only possible online using the following link: portal.graduatecenter-lmu.de/i-target. The application portal will be open from may May 19th through June 20th 2014. For any inquiries concerning the program or the application process, please contact the i-Target staff: itarget@med.uni-muenchen.de. Please note that applications submitted by email will not be considered.

Research Area 1: Targeted cellular therapy

  • A: Arming tumor specific T cells with CC motive receptors

    Principle investigators: PD Dr. Sebastian Kobold and Prof. Stefan Endres

    Brief description: Adoptive T cell therapy is one of the most promising approaches for the treatment of cancer. A major limitation is the infiltration or homing of the transferred T cells to the tumor site. The aim of this PhD-project will be to overexpress defined chemokine receptors on tumor-specific T cells to enhance the efficacy of adoptive T cell therapy. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

  • B: Enhancing T cell therapy through activating receptors

    Principle investigators: PD Dr. Sebastian Kobold and Prof. Stefan Endres

    Brief description: Tumors mount an effective immunosuppressive milieu to prevent immune cells to efficiently recognize tumor cells and suppress their activity. The aim of this Ph. D. project will be to overexpress in-house engineered activating receptors to enhance the efficacy of adoptive T cell therapy. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

  • C: Engagement of T cells through bispecific antibodies

    Principle investigators: PD Dr. Sebastian Kobold and Prof. Stefan Endres

    Brief description: Bispecific antibodies have the great advantage of specific targeting of two different antigens, allowing for both immune and tumor cell binding. The aim of this Ph. D. project will be to design and use new bispecific antibodies to enhance the efficacy of adoptive T cell therapy. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

  • D: Therapeutic vaccines and immune check point blockade in leukemia

    Principle investigator: PD Dr. Marion Subklewe; Department of hematology / oncology, University Hospital of the Ludwig-Maximailians-Universität, Munich, Germany

    Brief description: We have documented the generation of superior dendritic cells (DCs) from monocytes of AML patients using a fast, TLR ligand-containing maturation cocktail. Based on our preclinical data, we have initiated a proof-of-concept trial using RNA-transfected DCs for postremission therapy in AML. Therapeutic vaccinations induced cellular immune responses may be hampered by upregulation of immune inhibitory molecules (“immune checkpoint markers”) on target cells.

    The aim of this Ph.D. project is to identify immuninhibitory pathways relevant in AML as mechanisms of immune escape and as therapeutic targets. The therapeutic potential of checkpoint inhibitors and other immunmodulatory drugs will be assessed in vitro and in collaboration also in an in vivo AML mouse model. The methods will comprise a wide range of cellular and immunological methods and will optionally include in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Medizinische-Klinik-und-Poliklinik-III/de/team/oberaerzte/subklewe_m

 

Research Area 2: Targeted immunomodulatory therapy

  • E: Development of innovative multispecific antibody derivatives for the specific recruitment of immune effector cells to tumor cells

    Principle investigator: Prof. Dr. rer. nat. Karl-Peter Hopfner

    Brief description: The project will involve a combination of protein engineering, protein biochemistry and functional studies (cell culture, cell lysis assays, FACS). In collaboration with other iTarget members, the final goal of the PhD thesis is to test the efficacy in mouse models.

    Homepage: www.hopfner.genzentrum.lmu.de

  • F: Identifying novel immunological epitopes for immunotherapy of acute myeloid leukemia.

    Principle investigators: Prof. Dr. Christoph Klein, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University, Munich, Germany.

    Brief description: In this Phd project we plan to develop a research pipeline to discover novel therapeutic targets for AML by deciphering key factors controlling myeloid cell differentiation. Thus we wish to study the potential role of novel targets in murine leukemia cells as well as the identification of novel pathways via genome-wide analysis of rare children with monogenetic diseases. We plan to design monoclonal antibodies and chimeric T-cell receptors recognizing specific membrane-bound proteins and anticipate that immune-targeting will selectively eliminate myeloid cells. Immune-effectors will be systematically assessed in vitro and in vivo for their capacity to recognize and kill myeloid leukemia cells. The methods will comprise a wide range of cellular, immunological and biochemical methods as well as in vivo experiments.

    Homepage: www.klein.genzentrum.lmu.de

  • G: Induction of anti-leukemic T-cell responses by bystander killing of CD33+ myeloid-derived suppressor cells via a CD33/CD3-bispecific BiTE® antibody construct

    Principle investigators: Prof. Dr. Andreas Mackensen and PD Dr. Dimitrios Mougiakakos, Department of Hematology and Oncology, University Hospital, Friedrich-Alexander-University, Erlangen, Germany

    Brief description: In recent years myeloid derived suppressor cells (MDSCs) have emerged as a key cell subset that promotes tumor immune escape. Strategies to overcome MDSC-mediated immune suppression hold promise to improve efficacy of modern immunotherapies. The aim of this PhD project is to (1) characterize MDSCs in patients with acute myeloid leukemia (AML) in order to (2) target them with a novel so-called CD33/CD3 bi-specific antibody (AMG330) showing a high anti-leukemic activity. In doing so we hope elicit two critical hits against AML. The methods utilized in this translational project will comprise a broad variety of cellular, molecular, and immunological techniques.

    Homepage: www.medizin5.uk-erlangen.de/en/research-teaching

 

Research Area 3: Targeted immunomodulatory therapy

  • H: Harnessing immune responses in hematological malignancies by redox remodeling

    Principle investigators: PD Dr. Dimitrios Mougiakakos and Prof. Dr. Andreas Mackensen, Department of Hematology and Oncology, University Hospital, Friedrich-Alexander-University, Erlangen, Germany

    Brief description: Emerging evidence suggest that tumor-associated oxidative stress weakens the patients’ immune system and thereby contributes to tumor immune escape and attenuates the efficacy of immune based therapies. In this PhD project we aim to (1) evaluate oxidative stress-induced immune alterations in patients with leukemia and to develop strategies for pharmacologically (2) antagonizing this metabolic condition and for (3) enhancing the resilience of immune cells towards it. The ultimate goal is to boost intrinsic anti-tumor immune responses and to increase the efficacy of immune based therapies. The methods utilized in this translational project will comprise a broad variety of cellular, immunological, and metabolic techniques.

    Homepage: www.medizin5.uk-erlangen.de/en/research-teaching

  • I: Combination of radiotherapy with Hsp90 inhibition to enhance the extent and the immunogenicity of tumor cell death for the treatment of sarcoma

    Principle investigators: Prof. Kirsten Lauber, Clinic for Radiotherapy and Radiation Oncology, Ludwig-Maximilians-Universität, Munich, Germany

    Brief description: The induction of immunogenic forms of cell death by specific radiotherapeutic regimes appears to be a promising approach for the stimulation of innate and adaptive anti-tumor immune responses. The aim of this PhD project is to explore, whether Hsp90 inhibition in combination with radiotherapy can enhance the extent as well as the immunogenicity of sarcoma cell death, and whether this can contribute to the stimulation of anti-sarcoma immune responses. To this end, various molecular, cell biological, and immunological methods will be employed, including in vivo experiments.

    Homepage: www.klinikum.uni-muenchen.de/Klinik-und-Poliklinik-fuer-Strahlentherapie-und-Radioonkologie/de/forschung/molek_onkologie/index.html

  • J: Card9 signaling in anti-tumor immunity

    Principle investigator: Prof. Jürgen Ruland, Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar der Technischen Universität München

    Brief description: T cell activation is controlled by signals from antigen-presenting cells (APCs). APCs express multiple distinct pattern recognition receptors that can respond to specific innate immune stimuli and trigger unique signaling pathways that can prime T cell responses in a differential manner. The downstream adapter protein Card9 is absolutely critical for this process. Using in vitro and in vivo techniques, the PhD student will characterize the role of Card9 in the induction of T cell responses and tumor immunity. Another major aim of the project is to investigate the role of innate immune effectors on tumor growth and survival and their role in the tumor environment.
    Homepage: www.klinchem.med.tum.de

  • K: Targeting myeloid-derived suppressor cells (MDSC) in pancreatic cancer with ligands of RIG-I like helicases (RLH)

    Principle investigator: Prof. Max Schnurr, Division of Clinical Pharmacology, University Hospitals, Ludwig-Maximilians-Universität, Munich, Germany

    Brief description: Pancreatic cancer is characterized by an immunosuppressive network involving immature myeloid cells, so called MDSCs. Reprogramming MDSCs from an immunosuppressive (M2) towards an immunogenic (M1) phenotype is a novel therapeutic approach for breaking immunosuppression in tumors. The aim of this PhD project will be to assess the influence of immune stimulatory RNA species that activate the cytosolic helicase RIG-I on MDSC functional profiles, both tumor-promoting and -inhibitory. The methods will comprise a wide range of cellular and immunological methods and will include in vivo experiments in murine pancreatic carcinoma models.

    Homepage: www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de

12 fellowships / scholarships Social Sciences (BAGSS)

The Bamberg Graduate School of Social Sciences (BAGSS)
invites applications for up to

12 fellowships / scholarships for doctoral candidates

These fellowships and scholarships are available from October 1st, 2014, for three years (sub­ject to satisfactory progress reviews after 12 and 24 months).

BAGSS is a multidisciplinary Graduate School funded by the German Science Foundation (DFG) as part of the German Excellence Initiative. We are seeking to stimulate and guide cutting-edge doctoral research on some of the most crucial challenges modern know­ledge-based societies are facing. Specialised research agendas have been grouped into four thematic pillars:

  • Pillar 1   Education, personal development and learning from early childhood to adulthood
  • Pillar 2   Education and social inequality across the entire life course
  • Pillar 3   Changes in human capital, labour markets and demographic structures and their
    impact on social inequality in modern societies
  • Pillar 4   Governance, institutional change and political behaviour

Qualification and requirements:

We are inviting applications from highly qualified graduates from the fields of Sociology, Psy­cho­logy, Educational Science, Political Science, Economics, Demography and Statistics. Qua­lified graduates of related subjects with a strong background in the empirical social sciences are also encouraged to apply. Candidates must hold a Master’s degree (or equivalent) in one of the aforementioned subjects or be very close to completion. Successful applicants will be re­quired to take up their residence in Bamberg, a city noted for its very high quality of life as well as great conditions for research and study.

Remuneration for the doctoral fellowships is based on Grade E 13 TV-L (50%) of the German Public Service Salary Scale. There is a teaching obligation of two hours per week for only one semester during the three years. Holders of the doctoral scholarships receive a monthly stipend of 1.365 Euro, plus family allowances and child-care expenses in accordance with the DFG guidelines where applicable.

The Graduate School is committed to diversity, equal opportunities and the compatibility of fa­mi­ly and career. It therefore explicitly encourages applications from women. As an in­ter­na­tio­nal research institution, the School particularly welcomes applications from abroad. Applicants with disabilities possessing essentially equivalent qualifications will receive preferential con­si­deration.

For further information about BAGSS, the application process and the required documents, please visit our website at www.uni-bamberg.de/bagss/application

The deadline for the submission of your application is Monday, March 31th, 2014.

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Canada Graduate Scholarships

The Vanier Canada Graduate Scholarships (Vanier CGS) program was created to attract and retain world-class doctoral students and to establish Canada as a global centre of excellence in research and higher learning. It is worth $50,000 per year for three years and is available to both Canadian and international PhD students studying at Canadian universities.

Deadline

The deadline date is November 6, 2013 (8:00 p.m. Eastern Time).

Canadian universities must submit all nominations to the Vanier-Banting Secretariat via ResearchNet by the deadline date.

Note: Each Canadian university has an internal deadline date for students to submit their applications. The Canadian university should be contacted for this information.

Review Process

Vanier Canada Graduate Scholarships are awarded after a competitive review process.

University review

Students must be nominated by an eligible Canadian university. The scholarship liaison officer at each eligible Canadian university is responsible for coordinating the university review to determine the selected candidates and forwarding those nominations to the Vanier-Banting Secretariat —the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC) or the Social Sciences and Humanities Research Council (SSHRC)—in accordance with their university’s allocation.

Selection committees

Once submitted to the Vanier-Banting Secretariat, each nomination is evaluated by an agency-specific selection committee. Each selection committee recommends the top 55 or 56 candidates (for a combined total among the three federal granting agencies of up to 167 candidates) to the Vanier-Banting steering committee based on the candidate’s academic excellence, research potential and leadership (potential and demonstrated ability).

 

Vanier-Banting steering committee

 

The Vanier-Banting steering committee, which is comprised of the presidents of the three federal granting agencies and the deputy ministers of Industry Canada and Health Canada make the final decisions on funding. Each year, the Vanier-Banting steering committee approves up to 167 Vanier Scholars for funding based on the recommendations of the agency-specific selection committees. The Vanier-Banting steering committee also oversees the program’s process, policies and results to ensure that the program achieves its objectives.

 

When can the Vanier CGS be taken up?

 

Once notified of the results, Vanier Scholars may take up their Vanier CGS on May 1, 2014, September 1, 2014 or January 1, 2015. The start date chosen must not overlap with any prior federal granting agency funding received and the Vanier Scholar must be registered for full-time studies at the Canadian university as of the Vanier CGS start date.

 

Supplementary Funding

 

Vanier Scholars who are citizens or permanent residents of Canada may also be eligible for supplementary funding. Please visit the following websites to view available opportunities:

 

 

Questions?

 

For more information regarding the Vanier CGS program, please contact: vanier@cihr-irsc.gc.ca.

Further Information

Application Deadline : 6 November 2013

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Austria : Doctoral Positions in the area of Financial Econometrics and Statistics

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Applicants should have an above-average degree in economics, statistics, econometrics, mathematics or related fields with a solid background in statistics, econometrics and empirical finance. The successful applicants are supposed to serve as teaching and research assistants and to collaborate with the research group of Prof. Nikolaus Hautsch on the borderline between statistics, econometrics and finance. They are expected to write a doctoral dissertation in statistics, econometrics or empirical economics/finance. Moreover, they are supposed to participate in one of the doctoral programs at Faculty of Business, Economics and Statistics. Good English language skills are indispensable.

To apply, please send your CV and certificates (by e-mail or post) to Madlen Stottmeyer.

Deadline: October 30th 2013

Further Information

Application Deadline : 31 October 2013

Download this Call as PDF

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Italy : 101 PhD positions at University of Trento

Admission to Research Doctorate can be done only by public selection. Announcements for Selection are published every year between February and July. For details about examination&# 39;s schedule please refer to the webpages of the selected doctoral school.

Available applications for Doctoral courses by the University of Trento are listed below.

International Doctoral School in Biomolecular Sciences 29 cycle
Deadline Thu 26 Sep 2013 16:00 (Italian time)

PhD Program in Humanities 29th cycle
Deadline Wed 25 Sep 2013 16:00 (Italian time)

Doctoral School in Mathematics 29th cycle
Deadline Wed 18 Sep 2013 16:00 (Italian time)

Doctoral School in Civil, Environmental and Mechanical Engineering 29th cycle
Deadline Mon 30 Sep 2013 16:00 (Italian time)

Doctoral School in Materials, Mechatronics and System Engineering 29th cycle
Deadline Tue 24 Sep 2013 16:00 (Italian time)

Doctoral School in Physics 29th cycle
Deadline Tue 10 Sep 2013 16:00 (Italian time)

Doctoral Course in Comparative and European legal studies 29th cycle
Deadline Wed 18 Sep 2013 16:00 (Italian time)

Further Information

Application Deadline : 26 September 2013

Universita' di Trento

Doctoral courses

PhD courses available at the University of Trento for the academic year 2013/2014 (29° cycle):

Scientific Area:

Humanities Area:

Cognitive Area:

 

Admission to Research Doctorate can be done only by public selection. Announcements for Selection are published every year between February and July. For details about examination’s schedule please refer to the webpages of the selected doctoral school.

Available applications for Doctoral courses by the University of Trento are listed below.

Scientific Area Doctoral Courses – Doctorate Office – Science and technology
Via Sommarive 14 – 38123 Povo – Trento
tel. +39 0461 281667 – 1669 – 2194
fax +39 0641 281699
dottorati-collina@unitn.it
Office opening hours: from Monday to Friday: 10.00-12.00.

Humanities Area Doctoral Courses – Doctorate Office
Via Verdi, 26 – 38122 Trento
tel. +39 0461 282188-1753-2193-1428-2377
fax +39 0461 282191
dottorati-citta@unitn.it
Office opening hours: from Monday to Friday: 10.00-12.00; Tuesday: 14.00-16.00.

Cognitive Area Doctoral Courses – Doctorate Office Rovereto
Corso Bettini, 84 – 38068 Rovereto
tel. +39 0464 808416
fax +39 0464 808407
dottorati-rovereto@unitn.it
Office opening hours: Monday: 10.00-12.00; Wednesday: 14.30-16.00; Friday: 10.00-12.00.

 

International Doctoral School in Biomolecular Sciences 29 cycle
Deadline Thu 26 Sep 2013 16:00 (Italian time)
Info Info Download Download
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PhD Program in Humanities 29th cycle
Deadline Wed 25 Sep 2013 16:00 (Italian time)
Info Info Download Download
Enter
Doctoral School in Civil, Environmental and Mechanical Engineering 29th cycle
Deadline Mon 30 Sep 2013 16:00 (Italian time)
Info Info Download Download
Enter
CIBIO – Declaration of Interest Form 2013
Deadline Wed 02 Oct 2013 01:00 (Italian time)
Info Info
Enter
Doctoral School in Materials, Mechatronics and System Engineering 29th cycle
Deadline Tue 24 Sep 2013 16:00 (Italian time)

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